Endocrine Abstracts

Aim: Thyroid cancer comprises the most common endocrine malignancy and a variety of studies have examined the role of TSH as an independent risk factor for the manifestation of differentiated thyroid cancer in otherwise benign thyroid disorders. Objective of the current retrospective study was the assessment of a possible relation between baseline serum TSH and thyroid microcarcinoma in a patient cohort with non-toxic thyroid disorders and without preoperative cytological esta...

Background: Prior to 2014 Portsmouth patients with Turners syndrome (TS) were seen in a variety of endocrine clinics. Screening investigations e.g. cardiac echo, necessitated further appointments. The Turners Syndrome Support Society (TSSS) recommend that ladies should be under the care of a specialist multi-disciplinary TS clinic, equipped to manage the specific medical problems associated with the syndrome.Innovation: Portsmouth Endocrine Department es...

Background: In men there is a strong relationship between androgens and erythropoiesis; however this has not been shown in women. Patients with congenital adrenal hyperplasia (CAH) if uncontrolled may have high androgen levels and if over treated with glucocorticoids low androgen levels. Therefore CAH provides a potential model to examine the relationship between androgens and erythropoiesis in women.Aim: To investigate the relationship between androgens...

Introduction: Aldosterone (Aldo) decreases the rate of repolarization in rabbit cardiomyocytes and significantly increases the duration of the monophasic action potential in patients with supraventricular arrhythmias, few minutes after its intravenous administration, implying for a non-genomic action. We have previously found a positive linear regression between left ventricular systole duration and plasma Aldo levels in NZW rabbits. To investigate the veracity of the above fi...

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

Introduction: The aim of this study was to systematically review the literature for studies that have investigated possible differences in prevalence of subclinical Cushing’s syndrome (SCS) and related clinical implications between patients with unilateral (UAI) and bilateral adrenal incidentalomas (BAI) and to meta-analyze the best evidence available.Methods: Electronic databases PubMed, MEDLINE and EMBASE were systematically searched. Main study o...

Introduction: Vitamin D deficiency has been reported to be widely found within the population. Vitamin D deficiency was also found to be prevalent in patients with autoimmune inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. Vitamin D deficiency was reported in almost all patients with acute myocardial infarction in a US multicenter study. Low concentrations of 25-hydroxyvitamin D (25(OH)D) are reported to be an independent risk factor for ca...

Introduction: Half of subjects following a low-calorie dietary program cannot tolerate its nutritional restrictions and abandon it. A realistic approach to overcome this obstacle is the addition of low glycaemic index (GI), low glycaemic load (GL) snacks in their nutrition. Stevia, a potent, low calorie natural sweetener exerts anti-hyperglycaemic and insulinotropic activities. Furthermore, Vitamin D deficiency may affect diabetes development in the long run.<p class="abst...

Background: Gastrin is an early incretin candidate, since it is released by oral glucose and potentiates the glucose-induced insulin secretion. It has been shown that only in hypoglycaemic or hyperglycaemic conditions gastrin release is influenced by changes in blood glucose and insulin concentrations.Aim: To evaluate whether there is a relation between fasting serum glucose and serum gastrin concentrations.Methods: Gastrin and glu...

Objective: To report a case of a patient diagnosed with latent autoimmune diabetes of adulthood (LADA) based on clinical presentation and positive glutamic acid decarboxylase antibodies (GAD-abs) that converted to antibody negative diabetes after combined treatment with sitagliptin and vitamin D.Methods: A 31-year-old male presented at the emergency room with symptoms of polyuria, polydipsia, and weight loss. Blood glucose was 300 mg/dl with mild ketonur...